Signaling through both the transforming growth factor β (TGFβ) superfamily of growth factors and Notch play crucial roles during embryonic pattern formation and cell fate determination. Although both pathways are able to exert similar biological responses in certain cell types, a functional interaction between these two signaling pathways has not been described. Now, three papers provide evidence of both synergy and antagonism between TGFβ and Notch signaling.1-3 These reports describe a requirement for Notch signal transducers in TGFβ- and BMP-induced expression (...) of Notch target genes, as well as in BMP-controlled cell differentiation and migration. These papers uncover a direct link between the Notch and TGFβ pathways and suggest a critical role for Notch in some of the biological responses to TGFβ family signaling. BioEssays 27:115–118, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Time underlies many interesting human behaviors. Thus, the question of how to represent time in connectionist models is very important. One approach is to represent time implicitly by its effects on processing rather than explicitly (as in a spatial representation). The current report develops a proposal along these lines first described by Jordan (1986) which involves the use of recurrent links in order to provide networks with a dynamic memory. In this approach, hidden unit patterns are fed back to themselves: (...) the internal representations which develop thus reflect task demands in the context of prior internal states. A set of simulations is reported which range from relatively simple problems (temporal version of XOR) to discovering syntactic/semantic features for words. The networks are able to learn interesting internal representations which incorporate task demands with memory demands: indeed, in this approach the notion of memory is inextricably bound up with task processing. These representations reveal a rich structure, which allows them to be highly context‐dependent, while also expressing generalizations across classes of items. These representations suggest a method for representing lexical categories and the type/token distinction. (shrink)

Although for many years a sharp distinction has been made in language research between rules and words—with primary interest on rules—this distinction is now blurred in many theories. If anything, the focus of attention has shifted in recent years in favor of words. Results from many different areas of language research suggest that the lexicon is representationally rich, that it is the source of much productive behavior, and that lexically specific information plays a critical and early role in the interpretation (...) of grammatical structure. But how much information can or should be placed in the lexicon? This is the question I address here. I review a set of studies whose results indicate that event knowledge plays a significant role in early stages of sentence processing and structural analysis. This poses a conundrum for traditional views of the lexicon. Either the lexicon must be expanded to include factors that do not plausibly seem to belong there; or else virtually all information about word meaning is removed, leaving the lexicon impoverished. I suggest a third alternative, which provides a way to account for lexical knowledge without a mental lexicon. (shrink)

Individuals vary in the way they navigate through space. Some take novel shortcuts, while others rely on known routes to find their way around. We wondered how and why there is so much variation in the population. To address this, we first compared the trajectories of 368 human subjects navigating a virtual maze with simulated trajectories. The simulated trajectories were generated by strategy-based path planning algorithms from robotics. Based on the similarities between human trajectories and different strategy-based simulated trajectories, we (...) found that there is a variation in the type of strategy individuals apply to navigate space, as well as variation within individuals on a trial-by-trial basis. Moreover, we observed variation within a trial when subjects occasionally switched the navigation strategies halfway through a trajectory. In these cases, subjects started with a route strategy, in which they followed a familiar path, and then switched to a survey strategy, in which they took shortcuts by considering the layout of the environment. Then we simulated a second set of trajectories using five different but comparable artificial maps. These trajectories produced the similar pattern of strategy variation within and between trials. Furthermore, we varied the relative cost, that is, the assumed mental effort or required timesteps to choose a learned route over alternative paths. When the learned route was relatively costly, the simulated agents tended to take shortcuts. Conversely, when the learned route was less costly, the simulated agents showed preference toward a route strategy. We suggest that cost or assumed mental effort may be the reason why in previous studies, subjects used survey knowledge when instructed to take the shortest path. We suggest that this variation we observe in humans may be beneficial for robotic swarms or collections of autonomous agents during information gathering. (shrink)

Individuals vary in the way they navigate through space. Some take novel shortcuts, while others rely on known routes to find their way around. We wondered how and why there is so much variation in the population. To address this, we first compared the trajectories of 368 human subjects navigating a virtual maze with simulated trajectories. The simulated trajectories were generated by strategy-based path planning algorithms from robotics. Based on the similarities between human trajectories and different strategy-based simulated trajectories, we (...) found that there is a variation in the type of strategy individuals apply to navigate space, as well as variation within individuals on a trial-by-trial basis. Moreover, we observed variation within a trial when subjects occasionally switched the navigation strategies halfway through a trajectory. In these cases, subjects started with a route strategy, in which they followed a familiar path, and then switched to a survey strategy, in which they took shortcuts by considering the layout of the environment. Then we simulated a second set of trajectories using five different but comparable artificial maps. These trajectories produced the similar pattern of strategy variation within and between trials. Furthermore, we varied the relative cost, that is, the assumed mental effort or required timesteps to choose a learned route over alternative paths. When the learned route was relatively costly, the simulated agents tended to take shortcuts. Conversely, when the learned route was less costly, the simulated agents showed preference toward a route strategy. We suggest that cost or assumed mental effort may be the reason why in previous studies, subjects used survey knowledge when instructed to take the shortest path. We suggest that this variation we observe in humans may be beneficial for robotic swarms or collections of autonomous agents during information gathering. (shrink)

When corporations are accused of unethical behaviour by external actors, executives from those organizations are usually compelled to offer communicative responses to defend their corporate image. To demonstrate the effect that corporate executives'' communicative responses have on third parties'' perception of corporate image, we present the Corporate Communicative Response Model in this paper. Of the five potential communicative responses contained in this model (no response, denial, excuse, justification, and concession), results from our empirical test demonstrate that a concession is the (...) most effective and robust communicative option. (shrink)

Levinas and the Philosophy of Religion Jeffrey L. Kosky Reveals the interplay of phenomenology and religion in Levinas’s thought. "Kosky examines Levinas’s thought from the perspective of the philosophy of religion and he does so in a way that is attentive to the philosophical nuances of Levinas’s argument.... an insightful, well written, and carefully documented study... that uniquely illuminates Levinas’s work." —John D. Caputo For readers who suspect there is no place for religion and morality in postmodern philosophy, (...) class='Hi'>Jeffrey L. Kosky suggests otherwise in this skillful interpretation of the ethical and religious dimensions of Emmanuel Levinas’s thought. Placing Levinas in relation to Hegel and Nietzsche, Husserl and Heidegger, Derrida and Marion, Kosky develops religious themes found in Levinas’s work and offers a way to think and speak about ethics and morality within the horizons of contemporary philosophy of religion. Kosky embraces the entire scope of Levinas’s writings, from Totality and Infinity to Otherwise than Being, contrasting Levinas’s early religious and moral thought with that of his later works while exploring the nature of phenomenological reduction, the relation of religion and philosophy, the question of whether Levinas can be considered a Jewish thinker, and the religious and theological import of Levinas’s phenomenology. Kosky stresses that Levinas is first and foremost a phenomenologist and that the relationship between religion and philosophy in his ethics should cast doubt on the assumption that a natural or inevitable link exists between deconstruction and atheism. Jeffrey L. Kosky is translator of On Descartes’ Metaphysical Prism: The Constitution and the Limits of Onto-theo-logy in Cartesian Thought by Jean-Luc Marion. He has taught at Williams College. Indiana Series in the Philosophy of Religion—Merold Westphal, general editor May 2001 272 pages, 6 1/8 x 9 1/4, bibl., index, append. cloth 0-253-33925-1 $39.95 s / £30.50. (shrink)

Books Received listing for: American Catholic Philosophical Quarterly: Journal of the American Catholic Philosophical Association. Winter2013, Vol. 87 Issue 1, p219-220. 2p.

The sixth and most recently published of the seven Heidegger manuscripts from his literary remains, The Event , is itself something of an event. If the Beiträge zur Philosophie was to set the stage for what has been received as an even more experimental Heidegger, then The Event in many ways might look back on that experimentation as yesterday’s news. The Event seems to begin where the Beiträge ended, as if there was no longer the need to justify its sentences (...) by means of an appeal to the historical tradition; in fact, such an appeal goes further towards confirming that tradition and its corresponding metaphysics than it does towards problematizing it. This is not to say that The Event progresses as if the historical tradition were no longer unfolding, but that it is much less concerned with trying to make sense of its own unfolding from out of some vaguely universal understanding of that tradition. In fact, while the Beiträge unceasingly attempted to make .. (shrink)

This essay concerns various difficulties encountered in the attempt to assess the relation between Heidegger and Nietzsche. More specifically, those difficulties are due to the notion and function of repetition in the texts of both Heidegger and Nietzsche. I attempt to provide an analysis of repetition in the Heidegger of Being and Time and surrounding texts (e.g., Plato’s Sophist and Grundbegriffe der aristotelischen Philosophie). Following this attempt, I then examine the transformed notion of repetition operative in the now famous text (...) written at the time of the Nietzsche lectures, Beiträge zur Philosophie (Vom Ereignis), a repetition that goes by the name of crossing (Übergang). In my presentation of crossing, I attempt to draw Heidegger and Nietzsche together through the repetition of crossing and that of eternal recurrence of the same. Finally, I argue that what draws Heidegger and Nietzsche together is also what prevents us from distinguishing them in any traditional way, a distinction that could then be followed by any number of judgments regarding historical influence. That is, that what draws the two to thinking is what both draws them together, which is abyssal repetition, and problematizes any attempt to distinguish them. (shrink)

Levinas holds that ethics provides a figure of philosophical thought that is not ordered metaphysically and so allows us to explicate the significance of God whose fate is not linked with that of metaphysics, and his descrip- tion of ethics permits philosophy to bypass historical revelations pre- served by religious traditions as it articulates this significance of God. Nevertheless, Levinas's attempt to save the name "God" for that which responsibility witnesses is troubled in several ways: the responsible self cannot tell, (...) and cannot tell us, whether its responsibility witnesses God since (1) both it and God are outside the order (metaphysics and consciousness) where identification would be possible and (2) the anonymity of this God and the trauma suffered by the self are disturbingly close to the menace of the anonymous il y a as that anonymity has been described in Levinas's earlier work. (shrink)

El filósofo político de la Temprana Edad Moderna, Benedicto Spinoza, es a menudo visto como el padre del método crítico histórico para el estudio de la Biblia. A partir del trabajo de contemporáneos, Spinoza construyó el fundamento metodológico sobre el cual más tarde levantaría la crítica histórica. En este trabajo se examina el trasfondo político de la crítica bíblica de Spinoza, colocando así la obra de Spinoza en su contexto socio-histórico. La Guerra de los Treinta Años y la agitación política (...) en la República holandesa proveen el trasfondo próximo de la teoría política de Spinoza y de su crítica bíblica. (shrink)

Ethics, Policy & Environment, Volume 14, Issue 2, Page 231-237, June 2011.

What might be thought of as religious longings, he argues, are crucial aspects of enchanting secularity when developed through encounters with these works of art.

The dissertation focuses on the work of Emmanuel Levinas. In claiming "ethics is first philosophy," Levinas helps overcome the perceived indifference to ethical concerns among post-modern thinkers. However, it is often overlooked that this claim is as much about philosophy as it is about the importance of ethics. The dissertation explains why Levinas' philosophy turns to ethics and what philosophy is capable of once it has adopted this ethical figure. ;The first section is devoted to Levinas' Totality and Infinity. There, (...) Levinas argues that ethics reorients philosophy by accomplishing the metaphysical desire for beings as such, what Levinas calls the absolutely other. A reading of Jacques Derrida's essay "Violence and Metaphysics" shows that Totality and Infinity is profoundly determined by a theological conceptuality and correlatively by forgetting the ontological difference. This suggests that the primacy of ethics depends on an anterior instance, thus rendering Levinas' first philosophy secondary. ;The second section of the dissertation positions Levinas' ethical philosophy within the tradition of phenomenological philosophy and its quest for a subject who is first or ultimate. Whereas Husserl practiced the reduction to the point where it reached consciousness, Levinas practices it to a point beyond that: responsibility. Ethics intervenes as a supplement to Husserl's phenomenology: ethics is added to phenomenology in order to explain its possibility at the same time as it replaces phenomenology with ethical descriptions. This section concludes by contesting the privilege that Levinas accords to ethics in the phenomenology of the subject. It does so by showing that Heidegger's Dasein analytic offers phenomenological philosophy a similar subject. ;The third section argues that in responsibility, phenomena appear which do not appear when the subject is consciousness. These include religious phenomena. The phenomenology of responsibility can thus be the basis for a philosophy of religion. Like the modern philosophy of religion figured in Hegel and Nietzsche, it articulates the rationality or significance of religious phenomena without recourse to the dogmatic authority of faith or historical tradition. However, a philosophy of religion issued from Levinas surpasses the origin of this tradition in the death of God and end of metaphysics. (shrink)

Exploring the concepts of ethics, morality, and decision-making for the law enforcement community, Decision Point: Real-Life Ethical Dilemmas in Law Enforcement offers an inside look at the difficult challenges officers confront every day as they face ethical decisions that could drastically alter the course of their careers. Through a series of real-life vignettes, the book reviews specific scenarios, the actual decisions that were made, and the consequences and implications of these decisions. Focusing on the critical thinking needed for making appropriate (...) decisions, it retrospectively discusses considerations that were or should have been evaluated at the time. An engaging text ideal for classroom use, the book offers discussion questions at the end of each chapter that can be used as assignments, group breakout discussions, or professor-facilitated discussions. (shrink)

An exploration of how the writings of Jürgen Habermas lend philosophical support to the universal validity of reason, thus reinforcing the foundation of humanism.